The UC Bot Garden was very interested in tobacco circa 1920-1940. Probably mostly from a financial point of view. William Setchell (director from 1902-1928) collected pipes in San Francisco. Thomas Goodspeed (director from 1928-1954) made many trips to South America collecting a variety of Nicotiana species. The idea was to improve on the commercial tobacco with hybridization. I'm not sure which one enjoyed their field trips more.
In bloom now in the crop garden at the UC Botanical Garden.
"Nicotine acts to increase the production of other chemicals in the brain known as neurotransmitters that affect brain function. ... Nicotine also produces long-term effects on the dopamine system, which is involved in reward, mood and addiction."
This quote is stolen from the web.
(intoxicating plants)